When the prespecified morning copeptin cutoff level of less than 2.6 pmol per liter after overnight water deprivation was used to identify patients with complete central diabetes insipidus, 5 the

Copeptin is a novel, independent prognostic marker improving currently used risk stratification of stroke patients. Ann Neurol 2009;66:799-808.

Copeptin (median, 4.2 pmol/L; range, 1–13.8 pmol/L) was detectable in 97.5% of 359 healthy individuals and was not associated with age. Median concentrations were considerably higher in men than women, increased significantly after exercise, and were influenced by fasting and water load. The normal range of plasma copeptin levels is from 1.0 to 13.8 pmol/l with higher median levels in men than in women according to two large physiological studies in healthy volunteers [26, 43]. The difference in gender is poorly understood, also because no significant changes during the menstrual cycle were observed [ 44 ]. Copeptin measurement has been shown to be useful in various clinical indications, including the diagnosis of diabetes insipidus and the monitoring of sepsis and cardiovascular diseases.

Copeptin combined with hypersensitive cardiac troponin T (hs-cTnT) is a new detection scheme, and its value in the early diagnosis of acute myocardial infarction is still unclear. Accordingly, the aim of this study is to evaluate the diagnostic value of copeptin combined with hypersensitive troponin T detection in early acute myocardial infarction. The cut-off level of copeptin was 4.4 pmol/L, whereas in ambulatory patients with central diabetes insipidus and patients with post-surgical central diabetes insipidus copeptin levels < 2.6 pmol/L and < 2.9 pmol/L, respectively, diagnosed diabetes insipidus [29, 30]. Indeed, recent studies have found promise in its use in managing sepsis as copeptin levels were found to distinguish normal controls from septic patients, and septic patients from septic shock patients [44]. It may also hold promise as a cardiology biomarker in conjunction with troponin for acute myocardial infarction rule out [45,46]. Patients were analyzed as a whole cohort (n = 20) and in a restricted "normal cohort" consisting of patients with normal preoperative copeptin concentration (<10 pmol/L) and perioperative uneventful course (n = 11). In the whole cohort, preoperative copeptin concentration was 7.0 pmol/L (interquartile range: 3.1-11 pmol/L).

2010-05-26 · In healthy volunteers and under rest, normal copeptin levels have 4.0-4.4 pmol/l as range with only 5% of values lying outside this range . Statistical analysis. A logarithmic transformation was performed to obtain a normal distribution for skewed variables (i.e. copeptin concentrations).

Ved copeptin < 21 pmol/l bør videre utreding for sentral diabetes insipidus vurderes. 2016-03-01 · The median copeptin plasma concentration was 4.2 pmol/L with a range between 1 and 13.8 pmol/L .

Indeed, recent studies have found promise in its use in managing sepsis as copeptin levels were found to distinguish normal controls from septic patients, and septic patients from septic shock patients [44]. It may also hold promise as a cardiology biomarker in conjunction with troponin for acute myocardial infarction rule out [45,46].

Accordingly, the aim of this study is to evaluate the diagnostic value of copeptin combined with hypersensitive troponin T detection in early acute myocardial infarction. The cut-off level of copeptin was 4.4 pmol/L, whereas in ambulatory patients with central diabetes insipidus and patients with post-surgical central diabetes insipidus copeptin levels < 2.6 pmol/L and < 2.9 pmol/L, respectively, diagnosed diabetes insipidus [29, 30]. Indeed, recent studies have found promise in its use in managing sepsis as copeptin levels were found to distinguish normal controls from septic patients, and septic patients from septic shock patients [44]. It may also hold promise as a cardiology biomarker in conjunction with troponin for acute myocardial infarction rule out [45,46]. Patients were analyzed as a whole cohort (n = 20) and in a restricted "normal cohort" consisting of patients with normal preoperative copeptin concentration (<10 pmol/L) and perioperative uneventful course (n = 11).

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13, 33 The difference in gender is poorly understood. Copeptin combined with hypersensitive cardiac troponin T (hs-cTnT) is a new detection scheme, and its value in the early diagnosis of acute myocardial infarction is still unclear. Accordingly, the aim of this study is to evaluate the diagnostic value of copeptin combined with hypersensitive troponin T detection in early acute myocardial infarction.

Seven patients (all with diabetes insipidus) had mild hypernatraemia (range 146–149 mmol/L) at the end of the test. Overall, the test burden was low, although nausea was a frequent symptom during arginine stimulation. As a Control Group, 30 healthy individuals with normal physical examination results were included.
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Normally, labeled synthetic peptides are used as quality controls in SRM The selected transition ions possessed m/z values were at least 30 m/z above or below UniProt, UMAN n- Symptoms Prediction neurophysi n 2-copeptin NGAL_

The serum copeptin level in HT females was a median of 251.9 [Q1–Q3: 151.1–298.7 pg/ml]) vs. controls (median, 76.68 [Q1–Q3: 15.85–197.9 pg/ml]) and the difference was statistically significant (p < 0.01). In normal conditions, plasma vasopressin concentration ranges from an undetectable level to approximately 5 pmol/L, a range of values one order of magnitude lower than that of most other peptidic hormones. copeptin plasma concentrations were 4.2 pmol/L (range: 1–13.8 pmol/L).

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[PDF] High salt intake increases copeptin but salt sensitivity is associated with fluid [PDF] Atrial Natriuretic Peptide in the high normal range is associated with

Patients with CDI had lower copeptin levels than patients with DH or SO (both P < 0.01) or those with NDI. Copeptin identified CDI with an AUC of 0.99 (95% CI 0.97–1.00), and a cut-off value ≤ 4.4pmol/L showed a sensitivity of 100% and a specificity of 99% to predict CDI. Indeed, recent studies have found promise in its use in managing sepsis as copeptin levels were found to distinguish normal controls from septic patients, and septic patients from septic shock patients [44]. It may also hold promise as a cardiology biomarker in conjunction with troponin for acute myocardial infarction rule out [45,46]. In the first study including 359 subjects, plasma copeptin levels ranged from 1.0 to 13.8 pmol/L with a median concentration of 4.2 pmol/L. 13 The second evaluation with over 700 randomly selected volunteers reported comparable results with plasma copeptin levels ranging from 1.0 to 13.0 pmol/L. 33 Both trials reported higher median plasma copeptin levels in men than in women, whereas no correlation with age was shown. 13, 33 The difference in gender is poorly understood. Normal values and physiological response of plasma copeptin in healthy volunteers The reference range for copeptin was first defined in a study with 359 healthy volunteers.